In the 2011 movie Limitless, a struggling author played by Bradley Cooper turns into one particular of the world’s smartest males after having an experimental drug identified as NZT-48. The character then proceeds to use his newfound intelligence to finish his novel, make mountains of funds on the stock marketplace, and to gain again the affection of his ladylove. Minimal a lot more than a MacGuffin in the film, the fictional miracle drug is centered, albeit really loosely, on an enigmatic course of cognitive-maximizing medicine identified as nootropics.

What are they?

Any food stuff, drug, or nutritional health supplement that improves (or statements to) a single or extra element of mental functionality, this kind of as interest, operating memory, or enthusiasm, could be viewed as a nootropic. Many of these substances, most likely even most, are promoted and marketed as so-known as ‘smart drugs’ to consumers on the world-wide-web. Still in spite of their eye-catching promises, couple nootropics have been formally examined and uncovered to enhance psychological operate. Currently we will discuss two cognitive enhancers that are more than just smoke and mirrors.


Derived from the racetam loved ones of medicine, Noopept is a effective peptide that is recommended as a nootropic in Russia. According to studies, it is up to 1000 occasions as powerful as other, a lot more well-known members of the racetam loved ones, this sort of as piracetam. But there is certainly far more to Noopept than its large potency. Identified primarily for its neuroprotective properties, the drug has been uncovered to increase memory in quite a few assessments. 1 these kinds of review available promising final results in the remedy of cognitive degeneration in human beings with Alzheimer’s sickness. For these factors and numerous much more, Noopept is considered and marketed as a good drug, or nootropic. In fact, it is presented as a nutritional complement in the United States and in most other nations. Only in Russia and neighboring nations is it bought as a prescription treatment.

In addition to its cognitive benefits, Noopept has also been analyzed for probable anxiolytic (anti-panic) attributes. In 1 human research, grownup subjects reported important improvements in amounts of stress and anxiety, irritability, and melancholy. Additional benefits on temper, rest, and restlessness had been also pointed out in individuals with cognitive impairment. Quite a few reports have been accomplished on animals with similar success with regard to nervousness and melancholy similar to extraneous aspects.


Another member of the racetam loved ones of medicine, Phenylpiracetam (Phenotropil) is a spinoff of piracetam with an included phenyl molecule. Like our earlier entry, it is much much better than prototypical racetam medication with higher neuroprotective homes. In other words, it could have cognitive advantages that other, less strong medication do not possess. Of system, the only way to gauge a drug’s success is to examination it, and Phenylpiracetam has been subjected to various scientific scientific studies. What have been the success?

There is quite a little bit of investigation to recommend that Phenylpiracetam is helpful at lowering the fee of cognitive drop triggered by organic and natural brain conditions these kinds of as dementia, as opposed to mind trauma. The drug also assisted reduce some of the most typical symptoms of cognitive drop, these as nervousness and despair, in numerous different scientific studies and medical trials.

Like Noopept, there is compelling proof that Phenylpiracetam has anti-depressant properties. In both animal research and human trials, the drug ameliorated depressive signs or symptoms in subjects with cognitive impairment. This might be thanks to its psychostimulatory consequences, which can enhance locomotor exercise for hrs on conclude.

Noopept and Phenylpiracetam comparison

Now that we know a little bit about these two nootropics, it is time to examine them head-to-head. But ahead of we do, it is vital to be aware that both of those of these drugs or dietary nutritional supplements have confirmed powerful at boosting cognitive functionality in some topics. As a final result, there is no winner or loser in this matchup, but merely a additional suitable variety primarily based on specific requirements. With that in thoughts, let us analyze the tale of the tape.

Noopept Phenylpiracetam

Drug spouse and children Racetam Racetam

Efficiency vs. Piracetam 1000 instances 60 instances

Classification(s) Neuroprotectant Neuroprotectant, Psychostimulant

Dosage 10-30mgs daily 100-200mgs everyday

What are the main distinctions?

In spite of the obvious discrepancy in strength, when we modify for dosage, Noopept and Phenylpiracetam are approximately equivalent in potency, with the edge going to Noopept. Two of the strongest cognitive enhancers obtainable, equally prescription drugs have been thoroughly tested in laboratory trials. As customers of the racetam relatives of drugs, they share related mechanisms of action with every single other and the prototypical racetam drug, piracetam. On the other hand, considerable discrepancies amongst the two nootropics have been observed throughout tests.


Just one key distinction amongst Phenylpiracetam and Noopept is that the former gives a mental improve mainly because it is a psychostimulant. What this suggests is that Phenylpiracetam generates a transient maximize in psychomotor activity that lasts for up to four several hours. In other phrases, it acts as a cognitive select-me-up whose effects have been verified in quite a few checks. Despite the fact that there is some proof that Noopept may well improve your temper because of its anxiolytic attributes, it does not show up to maximize psychomotor activity since it is not a stimulant.


Just as in the movie Limitless, the effects of most intelligent prescription drugs are ephemeral, generally lasting only a few hours. Researchers have also observed that end users tend to establish up a tolerance to these drugs in brief get. These types of is the case with Phenylpiracetam, which delivers a quick mind strengthen when employed episodically. On the other hand, when consumers take the drug on a common, day by day basis, they do not receive the same stimulative outcomes mainly because of tolerance. Noopept, on the other hand, does not seem to share that shortcoming.

Researchers are not guaranteed why this is, but the potent nootropic can be taken for significantly extended intervals of time without the person setting up up considerably of a tolerance. In accordance to many reports, Noopept’s results are cumulative, which usually means that the drug will construct up in the physique about time. With that explained, the accumulation requires substantially lengthier, normally about 1 to two months before buyers working experience peak rewards. As a outcome, most customers cycle on and off of Noopept each 7 days or fortnight. The benefits of this application incorporate improved focus and improved memory recall/retrieval.

Stress and anxiety and melancholy

Though the mechanism of motion stays a mystery, both Noopept and Phenylpiracetam have anxiolytic houses. One concept is that both equally medicine encourage benzodiazepine receptors in the hippocampus place of the mind, which may perhaps help simplicity anxiousness and depression. But even so they function, the two nootropics have demonstrated effective in several experiments, specifically on subjects with cognitive impairment.

It is critical to notice, even so, that Noopept has been examined much more completely for anxiolytic properties than Phenylpiracetam, including both animal scientific tests and human trials. By comparison, the efficacy of Phenylpiracetam for managing indicators of nervousness and despair has only been examined in rats. This does not necessarily mean that the drug is ineffective at managing these diseases, but simply that a lot more investigate is wanted.

When to use Noopept

A strong nootropic that provides peak efficiency in one to two weeks, Noopept is a person of the several good medicine that can be made use of on a normal basis. Whether or not you are using a complicated college or university course or are doing the job as a summer season intern in a very competitive ecosystem, Noopept can present elevated aim, improved memory remember/retrieval, and better discovering capacity. It is no question Noopept is a person of the hottest nootropics on the current market these days.

When utilized responsibly, the drug/dietary complement has number of aspect effects. Compared with most other nootropics, Noopept does not trigger problems or sleep problems. The most popular grievances are minimal GI tract troubles these types of as belly aches. Usually the effects of too much consumption, the issue can usually be solved by reducing down to the encouraged dosage.

When to use Phenylpiracetam

Practically as potent as Noopept, Phenylpiracetam stimulates the thoughts and human body, escalating mental concentration and actual physical strength at the identical time. Totally analyzed in the lab and the field, the preferred nootropic increases cognitive perform, in distinct learning and difficulty solving. Its only notable flaw looks to be that consumers make up a tolerance to Phenylpiracetam very rapidly. In accordance to the investigate, peak positive aspects are arrived at just after only a few of times of use. As a consequence, Phenylpiracetam is not a health supplement that really should be taken routinely.

A lot like the fictional drug NZT-48, Phenylpiracetam delivers brief bursts of power and brainpower that fade rapid. As such, it operates very best when you know that you will require to concentrate intensely on a thing for a quick period of time. Not surprisingly, Phenylpiracetam is preferred with faculty pupils who consider it through all-night cram classes before a significant examination. It can also give the necessary psychological stamina to meet a looming task or get the job done deadline. Just be informed that the cognitive enhancer only functions for about four hours at a time, immediately after which time the stimulative positive aspects will recede.

As with any new medication or dietary supplement, new end users may well knowledge side effects when they start using Phenylpiracetam. Relatively slight as opposed to other medicines, some users have described bouts of gastrointestinal pain, headache, nausea, and irritability. Like most good prescription drugs, there is no recognized drug conversation with other remedies or dietary supplements or chance of actual physical habit with Phenylpiracetam.


Whilst not the wonder mind boosters we see in the films, Noopept and Phenylpiracetam are legitimate clever medication that can improve mental functionality in some people today. Substantial screening has also disclosed that the two nootropics support ease thoughts of anxiety and despair, specifically in people with cognitive impairment. Of program for most individuals, these medicine are utilized to increase mental purpose, memory, and determination – if only for a shorter when.